Agonis antidote,When the spread of poison becomes uncontrollable by mantra and tantra procedures and when the fifth phase of poison is over but the seventh phase is not over, prativisha (antitoxic substances) are to be made use of. This is the last resort in the treatment of poison and hence should be used only in extreme cases. Inanimate poison act upwards and animate poisons act downwards these opposing nature of actions of the said poisons are effectively made use of in prativisha therapy.